Search results for " healthy volunteer"

showing 8 items of 8 documents

A Hazelnut-Enriched Diet Modulates Oxidative Stress and Inflammation Gene Expression without Weight Gain

2019

Introduction. Inflammation is associated with obesity condition and plays a pivotal role in the onset and progression of many chronic diseases. Among several nutraceutical foods, hazelnuts (Corylus avellana L.) are considered an excellent anti-inflammatory and hypolipidemic food being the second richest source of monounsaturated fatty acids among nuts and because they are rich in vitamins, minerals, and phenolic compounds. Materials and Methods. A prospective pilot clinical trial on 24 healthy volunteers who consumed daily, as a snack, 40 g of hazelnuts (261.99 kcal/1096.17 kJ) for six weeks was conducted. Anthropometric measurements, body composition analysis, and nutrigenomic analysis on …

0301 basic medicineAgingAntioxidantArticle Subjectmedicine.medical_treatmentGene ExpressionInflammationPilot Projects030204 cardiovascular system & hematologyBiologymedicine.disease_causeSettore BIO/09BiochemistryCalcitriol receptorCorylus; Gene Expression; Healthy Volunteers; Humans; Inflammation; Middle Aged; Obesity; Oxidative Stress; Pilot Projects; Prospective Studies03 medical and health sciences0302 clinical medicineNutraceuticalCorylusmedicineHumansFood scienceObesityProspective Studieslcsh:QH573-671Inflammationlcsh:CytologySettore BIO/12Cell BiologyGeneral MedicineMiddle Agedmedicine.diseaseObesityHealthy VolunteersOxidative Stress030104 developmental biologyMethylenetetrahydrofolate reductasebiology.proteinClinical Studymedicine.symptomWeight gainOxidative stress
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Plasma leptin and vascular endothelial growth factor (VEGF) in normal subjects at high altitude (5050 m)

2013

Context: High altitude (HA) is a model of severe hypoxia exposure in humans. We hypothesized that nocturnal hypoxemia or acute maximal exercise at HA might affect plasma leptin and VEGF levels. Objectives: Plasma leptin, VEGF and other metabolic variables were studied after nocturnal pulse oximetry and after maximal exercise in healthy lowlanders on the 3rd-4th day of stay in Lobuche (5050 m, HA) and after return to sea level (SL). Results: Leptin was similar at SL or HA in both pre- and post-exercise conditions. Pre-exercise VEGF at HA was lower, and cortisol was higher, than at SL, suggesting that nocturnal intermittent hypoxia associated with periodic breathing at HA might affect these v…

AdultLeptinMaleVascular Endothelial Growth Factor Amedicine.medical_specialtyperiodic breathingPhysiologySettore MED/10 - Malattie Dell'Apparato RespiratorioBiologyNocturnalSettore BIO/09 - FisiologiaNOHypoxemiachemistry.chemical_compoundPhysiology (medical)Internal medicinemedicineHumanssleepExercisemaximal exercise testhypoxiaAltitudeHypoxia maximal exercise test metabolism periodic breathing sleepLeptinHypoxia; Maximal exercise test; Metabolism; Periodic breathing; Sleep; Adult; Exercise; Female; Humans; Hypoxia; Leptin; Male; Oxyhemoglobins; Vascular Endothelial Growth Factor A; Altitude; Healthy Volunteers; Physiology; Physiology (medical)hypoxia; maximal exercise test; sleep; periodic breathing; metabolismIntermittent hypoxiaGeneral MedicineHypoxia (medical)Effects of high altitude on humansHealthy VolunteersVascular endothelial growth factorEndocrinologychemistryOxyhemoglobinsPeriodic breathingFemalemedicine.symptommetabolismArchives of Physiology and Biochemistry
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Selective activation of shoulder, trunk, and arm muscles: A comparative analysis of different push-up variants

2015

Context The push-up is a widely used exercise for upper limb strengthening that can be performed with many variants. A comprehensive analysis of muscle activation during the ascendant phase (AP) and descendant phase (DP) in different variants could be useful for trainers and rehabilitators. Objective To obtain information on the effect of different push-up variants on the electromyography (EMG) of a large sample of upper limb muscles and to investigate the role of the trunk and abdomen muscles during the AP and DP. Design Cross-sectional study. Setting University laboratory. Patients or Other Participants Eight healthy, young volunteers without a history of upper extremity or spine injury.…

AdultMalemedicine.medical_specialtyShoulderPhysical TherapyFitneContext (language use)Physical Therapy Sports Therapy and RehabilitationFitness; Kinesiology; Rehabilitation; Training; Orthopedics and Sports Medicine; Physical Therapy Sports Therapy and RehabilitationElectromyographySports Therapy and RehabilitationPhysical medicine and rehabilitationFitnessmedicineHumansTrainingOrthopedics and Sports MedicineMuscle SkeletalExerciseOriginal ResearchAbdominal MusclesCross-Sectional StudieAnalysis of VarianceSettore M-EDF/02 - Metodi E Didattiche Delle Attivita' SportiveKinesiologymedicine.diagnostic_testbusiness.industryElectromyographyRehabilitationTorsoMuscle activationGeneral MedicineFitness; Kinesiology; Rehabilitation; Training; Abdominal Muscles; Adult; Analysis of Variance; Arm; Cross-Sectional Studies; Electromyography; Exercise; Female; Healthy Volunteers; Humans; Male; Muscle Skeletal; Shoulder; Spine; Torso; Orthopedics and Sports Medicine; Physical Therapy Sports Therapy and RehabilitationTorsoKinesiologyTrunkHealthy VolunteerHealthy VolunteersSpinemedicine.anatomical_structureCross-Sectional StudiesPush-upArmUpper limbAbdominal MuscleFemalebusinessHuman
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Head-to-head comparison of plasma cTnI concentration values measured with three high-sensitivity methods in a large Italian population of healthy vol…

2019

Abstract Background The study aim is to compare cTnI values measured with three high-sensitivity (hs) methods in apparently healthy volunteers and patients admitted to emergency department (ED) with acute coronary syndrome enrolled in a large multicentre study. Methods Heparinized plasma samples were collected from 1511 apparently healthy subjects from 8 Italian clinical institutions (mean age: 51.5 years, SD: 14.1 years, range: 18–65 years, F/M ratio:0.95). All volunteers denied chronic or acute diseases and had normal values of routine laboratory tests. Moreover, 1322 heparinized plasma sample were also collected by 9 Italian clinical institutions from patients admitted to ED with clinica…

Male0301 basic medicineprincipal component analysisvery elderlyClinical BiochemistryheparinizationBiochemistryPatient Admission0302 clinical medicineReference ValuesLimit of Detectionblood analysisTroponin IHealthy volunteers80 and overMyocardial infarctionAcute coronary syndrome; Cardiac troponins; High-sensitivity methods; Myocardial infarction; Reference population values; Acute Coronary Syndrome; Adolescent; Adult; Aged; Aged 80 and over; Blood Chemical Analysis; Female; Humans; Italy; Male; Middle Aged; Myocardium; Patient Admission; Reference Values; Troponin I; Young Adult; Emergency Service Hospital; Healthy Volunteers; Limit of DetectionReference population valuescomparative studyHigh-sensitivity methodsAged 80 and overemergency wardEmergency Servicehospital emergency servicetroponin I acute coronary syndromeSettore BIO/12clinical trialGeneral Medicinecardiac troponin 1 CLIAMiddle AgedHealthy Volunteerspriority journalItaly030220 oncology & carcinogenesisCardiac troponinFemaleAcute coronary syndromeEmergency Service HospitalAdultmedicine.medical_specialtyAcute coronary syndromecardiac muscleAdolescentHead to headheart infarctionArticleYoung AdultHospital03 medical and health sciencesbloodInternal medicinemedicinesexHumanscontrolled studyADVIA Centaurdiagnostic test accuracy studyhumannormal humanproceduresAgedbusiness.industryMyocardiumTroponin IBiochemistry (medical)reference valueEmergency departmentmedicine.diseasemajor clinical studyhospital admissionyoung adult Acute Coronary SyndromeHigh-sensitivity methodMyocardial infarctionmulticenter study030104 developmental biologySettore BIO/12 - Biochimica Clinica E Biologia Molecolare Clinicaageprotein blood levelReference valuesCardiac troponinsbusinessmetabolismBlood Chemical Analysis
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Echocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study

2015

International audience; AIMS: Reference values for Doppler parameters according to age and gender are recommended for the assessment of heart physiology, specifically for left ventricular (LV) diastolic function. In this study, we report normal reference ranges for Doppler parameters obtained in a large group of healthy volunteers. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following Doppler acquisition and measurement protocols approved by the European Association of Cardiovascular Imaging. METHODS AND RESULTS: A total of 449 (mean age: 45.8 ± 13.7 years) healthy volunteers (198 men and 251 women) were enrolled at the collaborating institutions…

MaleAgingLeft030204 cardiovascular system & hematologyDoppler echocardiographyVentricular Function LeftNORRE StudyCohort Studies0302 clinical medicineDiastoleReference ValuesNuclear Medicine and ImagingVentricular Function030212 general & internal medicineDoppler echocardiography; NORRE Study; reference values; systolic and diastolic function; Adult; Age Factors; Aged; Aging; Cohort Studies; Diastole; Echocardiography Doppler; Europe; Female; Healthy Volunteers; Heart Ventricles; Humans; Male; Middle Aged; Reference Values; Sex Factors; Systole; Ventricular Function Left; Young Adult; Radiology Nuclear Medicine and Imaging; Cardiology and Cardiovascular Medicinesystolic and diastolic functionmedicine.diagnostic_testDopplerAge FactorsGeneral MedicineMiddle AgedEchocardiography DopplerHealthy VolunteersCardiovascular physiologyEuropemedicine.anatomical_structureEchocardiographyCardiologysymbolsFemale[SDV.IB]Life Sciences [q-bio]/BioengineeringRadiologyCardiology and Cardiovascular MedicineDoppler effectCohort studyAdultmedicine.medical_specialtySystoleHeart VentriclesDiastole03 medical and health sciencessymbols.namesakeYoung AdultSex FactorsInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingSystoleAgedbusiness.industryreference valueDoppler echocardiographyVentricleReference valuesbusiness
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Postural control and balance in a cohort of healthy people living in Europe: An observational study

2018

Abstract In the past 20 years, posturography has been widely used in the medical field. This observational study aimed to report the values derived from posturography of a wide set of healthy subjects from various European countries using a plantar pressure platform and a standardized method of measurement. A random cluster sampling of 914 healthy subjects aged between 7.0 and 85.99 years, stratified by age, was carried out. To provide percentile values of our cohort, data were processed to obtain 3 curves corresponding to the following percentiles: 25th, 50th, 75th, and the interquartile range. Distance-weighted least squares method was used to represent the percentile on appropriate graph…

MalePercentileAgingpostural controlCohort Studies0302 clinical medicineReference ValuesPostural Balance80 and overMedicineAge FactorReference ValueYoung adultChildPostural BalanceAged 80 and over6600balance ; normative data ; normative values ; postural control ; posturographyMedicine (all)posturographyAge FactorsGeneral MedicineMiddle Agednormative dataHealthy VolunteerHealthy VolunteersEuropenormative valuesVestibular Function TestCohortFemaleHumanResearch ArticleCohort studyAdultmedicine.medical_specialtyBiometryAdolescentPostureObservational Study03 medical and health sciencesYoung AdultPhysical medicine and rehabilitationAdolescent; Adult; Age Factors; Aged; Aged 80 and over; Aging; Biometry; Child; Cohort Studies; Europe; Female; Healthy Volunteers; Humans; Least-Squares Analysis; Male; Middle Aged; Posture; Reference Values; Vestibular Function Tests; Young Adult; Postural Balance; Medicine (all)HumansLeast-Squares AnalysisBalance (ability)AgedLeast-Squares AnalysiSettore M-EDF/02 - Metodi E Didattiche Delle Attivita' Sportivebusiness.industryPosturographybalance030229 sport sciencesVestibular Function TestsObservational studyCohort Studiebusiness030217 neurology & neurosurgery
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Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)

2016

Background & Aims: A novel family of proton-sensing G-proteinâcoupled receptors, including ovarian cancer G-proteinâcoupled receptor 1 (OGR1) (GPR68) has been identified to play a role in pH homeostasis. Hypoxia is known to change tissue pH as a result of anaerobic glucose metabolism through the stabilization of hypoxia-inducible factor-1α. We investigated how hypoxia regulates the expression of OGR1 in the intestinal mucosa and associated cells. Methods: OGR1 expression in murine tumors, human colonic tissue, and myeloid cells was determined by quantitative reverse-transcription polymerase chain reaction. The influence of hypoxia on OGR1 expression was studied in monocytes/macrophages and…

WT wild type0301 basic medicineMM6 MonoMac 6HV healthy volunteerSPARC secreted protein acidic and rich in cysteineNF-κB nuclear factor-κBInflammationBiologyIEC intestinal epithelial cell03 medical and health sciencesIntestinal mucosaTDAG8Ovarian Cancer G-Protein–Coupled ReceptormedicineOGR1 ovarian cancer G-protein–coupled receptor 1 (GPR68)IFN interferonlcsh:RC799-869ReceptorOriginal ResearchTh T-helperInflammationTNF tumor necrosis factorIBD inflammatory bowel diseaseHepatologyRT-qPCR quantitative reverse-transcription polymerase chain reactionAICAR 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranosideTDAG8 T-cell death-associated gene 8 (GPR65)Inflammatory Bowel DiseaseGRP65GastroenterologyHypoxia (medical)Molecular biologyGPR G-protein–coupled receptormRNA messenger RNAIL interleukinChIP chromatin immunoprecipitationHIF hypoxia-inducible factorUC ulcerative colitis030104 developmental biologyHypoxia-inducible factorsCancer researchCD Crohn's diseaselcsh:Diseases of the digestive system. GastroenterologyTumor necrosis factor alphaFCS fetal calf serummedicine.symptomChromatin immunoprecipitationHomeostasisCellular and Molecular Gastroenterology and Hepatology
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Oxidative stress and antioxidant levels in patients with anorexia nervosa: A systematic review and exploratory meta-analysis.

2015

Objective To systematically review and meta-analyze oxidative stress and antioxidant markers in anorexia nervosa (AN). Methods Electronic PubMed search from database inception until 12/31/2013. Out of 1062 hits, 29 studies comparing oxidative stress/antioxidant markers between patients with AN and healthy controls (HCs) with a total of 1,729 participants (AN-=-895, HCs-=-834) were eligible. Data about oxidative stress and antioxidant markers, independent of their source, were extracted. We calculated random effects standardized mean differences (SMDs) as effect size measures for outcomes reported in ≥5 studies; others were summarized descriptively. Results Compared to HCs, AN patients showe…

oxidative streantioxidantAnorexia NervosaAntioxidantsHealthy VolunteersOxidative StressYoung AdultCross-Sectional StudiesPsychiatry and Mental Healthhealthy controlsHumansFemaleanorexia nervosa; antioxidant; healthy controls; oxidative stress; Anorexia Nervosa; Antioxidants; Biomarkers; Cross-Sectional Studies; Female; Healthy Volunteers; Humans; Oxidative Stress; Young Adult; Psychiatry and Mental HealthBiomarkersThe International journal of eating disorders
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